Exploring cellular heterogeneity and regulatory networks in nervous system development and disease.
Utilizing scRNA-seq, scATAC-seq, and spatial transcriptomics to construct high-resolution neural cell atlases.
Studying neural stem cell differentiation and the pathological basis of neurodegenerative diseases like Alzheimer's.
Developing computational methods using R (Tidyverse) and Python for integrating multi-modal omics data.
The project focuses on regulatory mechanisms of astrocyte heterogeneity in neuroinflammation.
Our study reveals epigenetic dynamic changes during early cortical development in primates for the first time.